(Blood-brain barrier，BBB）)
ʻO ka pale koko-lolo kekahi o nā mea koʻikoʻi koʻikoʻi no ka pale ʻana i ke kanaka.Hoʻokumu ʻia ia me nā cell endothelial capillary brain, glial cell, a me choroid plexus, e ʻae wale ana i nā ʻano mole mai ke koko e komo i nā neurons lolo a me nā ʻāpana ʻē aʻe a puni, a hiki ke pale i nā mea ʻino mai ke komo ʻana i ka ʻiʻo lolo.ʻO ka lolo, ma ke ʻano he ʻāpana huna a koʻikoʻi o ke kino o ke kanaka, mālama i nā hana koʻikoʻi.Hiki i ka pale koko-lolo ke pale i nā mea ʻino i loko o ke koko a pale i ka palekana o ka lolo.
ʻO ka maʻi o Alzheimer，AD
ʻO ka maʻi o Alzheimer (AD) kahi maʻi neurodegenerative holomua me ka hoʻomaka hoʻopunipuni.Ma ka hoʻomaʻamaʻa hoʻomaʻamaʻa, hōʻike ʻia ka dementia holoʻokoʻa e ka hōʻino hoʻomanaʻo, aphasia, aphasia, nalowale o ka ʻike, hōʻino ʻia o nā mākau ʻike maka a me nā spatial, nā hana hoʻokō, a me nā loli pilikino a me nā ʻano.ʻAʻole ʻike ʻia ka etiology.ʻO ka dementia mua e pili ana i nā poʻe e ulu ana i nā hōʻailona ma mua o ka makahiki 65;ʻO ka poʻe i hoʻomohala i ka dementia ma hope o ke 65 o kona mau makahiki i kapa ʻia ʻo senile dementia.Hoʻopili pinepine ʻia ka loaʻa ʻana o ka maʻi o Alzheimer (AD) me ka β-Amyloid protein (A β） Accumulation a me Tau protein entanglement i hoʻopili ʻia, a ʻoi aku ka nui o nā noiʻi e hoʻopaʻa haʻahaʻa nei i ka neuroinflammation ma ke ʻano he kumu e hāpai ai i ka hiki ʻana o AD.
Quote: He aha ka maʻi o Alzheimer?E nānā i kēia ʻike.Kanaka i kēlā me kēia lā ma ka pūnaewele.2023-09-20
E hoʻomanaʻo, aia kekahi ʻano bacteria e hiki ke komo i ka pale koko-lolo
I kēia mau lā, ua paʻi nā mea noiʻi mai Baylor College of Medicine ma ʻAmelika Hui Pū ʻIa i kahi pepa noiʻi i kapa ʻia: Toll like receptor 4 a me CD11b i hōʻike ʻia ma ka microglia coordinate erasure o Candida albicans cerebral mycosis ma ka Cell Reports sub journal.
Ua ʻike mākou i kahi haʻuki i kapa ʻia ʻo Candida albicans hiki ke komo i ka lolo ma ke kahe koko.E like me ka ʻōlelo kaulana, "ʻO ke kīkē ʻana i ka wāwae o ka ʻoʻopa hiki ke hoʻololi i ka maʻi o Alzheimer."I loko o kēia haʻawina, ua hōʻike hou mākou i nā hana molekala a Candida albicans e haki ai i ka pale koko-lolo a komo i ka lolo, e alakaʻi ana i ka maʻi Alzheimer e like me nā loli.
Pehea ke komo ʻana o Candida albicans i ka lolo?"Ua ʻike mākou ua hoʻopuka ʻo Candida albicans i kahi enzyme i kapa ʻia ʻo secreted aspartate protease (Saps), ka mea e hoʻopau ai i ka pale koko-lolo, e ʻae ai i nā fungi e komo i ka lolo a hana ʻino," wahi a Kauka Yifan Wu, he kanaka ʻepekema pediatric postdoctoral e hana ana ma Corry. Hale Hana.
ʻO Candida albicans
ʻO Candida albicans (inoa ʻepekema: Candida albicans) he hū hiki ke hoʻoulu i nā maʻi kūpono.Loaʻa maʻamau ia i loko o ke kaiāulu bacteria o ka digestive kanaka a me nā ʻāpana urogenital.Ma kahi o 40% a 60% o nā poʻe mākua olakino i loaʻa iā Candida albicans i kā lākou waha a me ka digestive tract.Noho pū nā Candida albicans me ke kino o ke kanaka, akā hiki ke ulu nui i ka wā o ka pale ʻole a hoʻoulu i ka candidiasis.ʻO ia ka maʻi bacteria maʻamau maʻamau i ka genus Candida
Wahi a kahi noiʻi ma Cell Reports, ʻo nā haʻani a mākou e nānā ʻole nui ai kekahi o nā mea hewa o ka maʻi o Alzheimer.Ua ʻike nā mea noiʻi mai Baylor School of Medicine a me nā hui hui pū ʻana ma o nā hiʻohiʻona holoholona pehea e komo ai ʻo Candida albicans i ka lolo a pehea ia e hoʻāla ai i ʻelua mau mīkini kūʻokoʻa i loko o nā pūnaʻi lolo e hoʻoikaika ai i kona ʻae ʻana (ʻo ia ka mea koʻikoʻi no ka hoʻomaopopo ʻana i ka ulu ʻana o ka maʻi o Alzheimer), a ua hana ʻia. ʻO ka protein β Amyloid (A β） Peptides (nā ʻāpana protein ʻona o ka protein amyloid) i manaʻo ʻia ʻo ia ke kumu o ka ulu ʻana o ka maʻi o Alzheimer.
Wahi a Kauka David Corry.ʻO David Corry ka Luna Hoʻokele o ka Pathology ma ka Fulbright Foundation a he kumu aʻoaʻo o ka pathology, immunology, a me ka lāʻau lapaʻau ma Baylor University.He lālā ʻo ia o ka Baylor L. Duncan Comprehensive Cancer Center.I ka makahiki 2019, ua ʻike mākou ua komo maoli ʻo Candida albicans i ka lolo a hana i nā loli like loa me ka maʻi o Alzheimer.Hoʻopili pinepine ʻia ka hū ʻana e Candida albicans
A β ʻO ke kumu o ka hana ʻana i nā amyloid like peptides ʻo ia ka hiki iā Sap ke hydrolyze i nā protein precursor amyloid (APPs).
Eia nō naʻe, ʻo kēia mau peptides ka mea e huki ai i ka manaʻo o nā cell immune lolo - microglia, he mea koʻikoʻi no ka hoʻomaʻemaʻe ʻana o Candida albicans e ka lolo ponoʻī.Eia kekahi, ʻo ka toxin Candidalysin i hana ʻia e Candida albicans e hoʻāla i ka microglia ma o kahi ala ʻē aʻe.Inā hoʻopau ʻia kēia ala, ʻaʻole hiki ke hoʻopau ʻia nā fungi i loko o ka lolo.
Hōʻike ka poʻe noiʻi e lilo paha kēia hana i puʻupuʻu koʻikoʻi no ka hoʻomaopopo ʻana i ke ʻano o ka maʻi o Alzheimer.Ua manaʻo nā haʻawina mua e pili ana nā protease i loko o ka lolo i ka haki ʻana o nā polokalamu a hāʻawi i ka A β ʻO ka hōʻiliʻili o ua kau i ke kumu.A i kēia manawa hiki ke hōʻoia ʻia hiki i kēia protease exogenous mai nā fungi ke hoʻoulu i ka hana like me A β Peptide.
Hōʻike ka poʻe noiʻi i ka loiloi hou ʻana i ke kuleana o Candida albicans i ka hoʻomohala ʻana i ka maʻi o Alzheimer e pono ai i ka wā e hiki mai ana, e alakaʻi paha i nā hoʻolālā lapaʻau hou no AD.
Mea kuhikuhi:
[1] ʻO Yifan Wu et al, Toll like me ka loaʻa 4 a me CD11b i hōʻike ʻia ma ka microglia coordinate erasure o Candida albicans cerebral mycosis, Cell Reports (2023) DOI: 10.1016/j.celrep.2023.113240
[2] Nā huahana maʻi maʻi lolo ʻO ka maʻi o Alzheimer e like me nā loli, wahi a ka noiʻi hou Loaʻa ʻia i ʻOkakopa 17, 2023 mai https://medicalxpress.com/news/2023-10-brain-fungal-infection-alzheimer-disease-like.html
Ka manawa hoʻouna: Dec-22-2023